|
KMID : 0387820140210010023
|
|
Clinical Pediatric Hematology-Oncology
2014 Volume.21 No. 1 p.23 ~ p.28
|
|
|
Prevalence of the Components of Metabolic Syndrome in Childhood Cancer Survivors
|
|
Shin Hye-Kyung
Choi Young-Jin
Lee Young-Ho
Shin Jeh-Hoon
Yang Seung
|
|
|
Abstract
|
|
|
Background: Childhood cancer survivors have been reported to have an increased risk of prevalence of metabolic syndrome compared to the normal population. The purpose of this study was to investigate the prevalence of the components of metabolic syndrome in childhood cancer survivors in a single institute.
Methods: The study included survivors who had survived for at least 5 years after off chemotherapy without evidence of recurrence. We measured body mass index (BMI), triglycerides (TG), high-density lipoprotein (HDL)?cholesterol, systolic and diastolic blood pressure, and fasting glucose.
Results: We investigated 58 childhood cancer survivors, median age 5.4 years (range, 0.1?17.2 years) at diagnosis and median follow-up time elapsed after off chemotherapy 7.4 years (range, 4.7?18.6 years). The frequency of metabolic syndrome was 3.4%. The prevalence of each component was: obesity, 17.2%; elevated TG level, 46.6%; low HDL cholesterol, 34.5%; elevated blood pressure, 1.7%; and elevated fasting glucose, 9.3%, respectively. Sixty nine percentage of survivors had at least 1 abnormal component of metabolic syndrome. The increased TG level was found more frequently in obese sub-jects than normal weight subjects.
Conclusion: We observed the high incidence of increased TG level in childhood cancer survivors. It is necessary to be closely monitored the components of metabolic syndrome in childhood cancer survivors, in order to prevent them from cardiovascular diseases and improve their health outcomes.
|
|
|
KEYWORD
|
|
|
Childhood cancer survivor, Metabolic syndrome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|